Rabson-Mendenhall syndrome in a 6-year-old girl.



How to Cite

Novoa M.P., Hernandez J.F., Florez J. 2022. Rabson-Mendenhall syndrome in a 6-year-old girl. Eur. J. Pediat. Dermatol. 32 (4):245-7. 10.26326/2281-9649.32.4.2371.


Novoa M.P. Hernandez J.F. Florez J.
pp. 245-7


Many factors such as obesity, growth hormone, glucagon and genetic defects are possible causes of insulin resistance, which results in a non-optimal response of the glucose metabolism and therefore an increased release of insulin. Insulin resistance is of a higher degree when it is linked to a genetic syndrome. Genetic syndromes of varying severity associated with insulin resistance have been identified (2, 3), ranging from the severe phenotype of Donohue syndrome to the milder phenotype of Rabson-Mendenhall syndrome. Patients initially have normal blood glucose values with concomitant increase in insulin levels; these changes are due to INRS mutations with impaired insulin clearance; a small percentage of patients have autoantibodies against INRS, which are responsible for impaired glycemic control […].


Rabson-Mendenhall syndrome, insulin resistance, child