Hypomelanotic macules: the most frequent and earliest cutaneous sign of tuberous sclerosis.
How to Cite
Bonifazi E., Schepis C. 2011. Hypomelanotic macules: the most frequent and earliest cutaneous sign of tuberous sclerosis. Eur. J. Pediat. Dermatol. 21 (2):97-112.
AbstractThe medical records of 40 children under the age of 13 years suffering from tuberous sclerosis were reviewed and the characteristics of the hypopigmented macules were analyz- ed. The latter were present in all cases, appeared in the first 6 months in 70% of cases, their average number was 6, affecting mainly the trunk and lower limbs. Their shape was in most cases elongate and reminiscent of a tuber or leaf, their outline was regular, their longer side was in most cases 2-4 cm and they were more visible in people with darker skin. Their differential diagnosis was discussed and finally, also on the basis of the literature, a variation of the relevant diagnostic criterion in tuberous sclerosis was proposed.
tuberous sclerosis, Hypomelanotic macules, Hypomelanosis