Aquagenic palmoplantar keratoderma and cystic fibrosis.


How to Cite

Mazzotta F. 2023. Aquagenic palmoplantar keratoderma and cystic fibrosis. Eur. J. Pediat. Dermatol. 33 (1):36-9. 10.26326/2281-9649.33.1.2453.


Mazzotta F.
pp. 36-9


Cystic fibrosis (CF) is the most frequent and serious of the rare inherited diseases. This is why scientific research is oriented towards the search for increasingly precocious and side-effect-free diagnostic methods. A possible dermatological marker of CF is the so-called aquagenic keratoderma (AK), which is a characteristic wrinkled appearance of the hands and sometimes of the feet that appears a few minutes after contact with water. A case of AK in a 4-year-old boy whose father and sister were healthy cariers of the F508 mutation stimulated discussion of genotype/phenotype relationships in AK and of the latest non-invasive methods for early diagnosis of CF.


aquagenic keratoderma, cystic fibrosis, child