Late onset hypermelanic verrucous epidermal nevus.

Abstract

This case, despite its banality, leads to some reflection. As for the time of onset, we are used to thinking that epidermal nevi are present from the earliest stages of life, perhaps becoming more evident with the passage of time as they become more warty. But if we remember that epidermal nevi are due to somatic mutations of HRAS, FGF3, PIK3CA (3) we must consider that these mutations are certainly more frequent during fetal life when cell multiplication is more intense, but they can also occur after birth (2, 5), or perhaps only becoming evident after birth following, for example, hormonal stimuli such as in Becker’s nevus or in some epidermal nevi during pregnancy (...).