Skin hyperpigmentation due to anticonvulsant drugs.


How to Cite

Bonifazi E. 2018. Skin hyperpigmentation due to anticonvulsant drugs. Eur. J. Pediat. Dermatol. 28 (1):64. 10.26326/2281-9649.28.1.1659.


Bonifazi E.
pp. 64


A melanic hyperpigmentation can be due to numerous endogenous and exogenous causes. Limiting ourselves to pharmacological causes only, we should remember (2) that a skin hyperpigmentation may be due to arsenic, chloroquine and hydroxychloroquine and to anticancer drugs such as bleomycin, cyclophosphamide, 5-fluorouracil, methotrexate etc.

Among the neuroleptic drugs the first place belongs to diphenylhydantoin: 10% of patients treated with this drug develop a chloasma-like hyperpigmentation probably due to direct action of the drug on melanocytes. Some patients treated with chlorpromazine for a long time have a blue-gray pigmentation of the photo-exposed areas, probably due to the formation of melanin-chlorpromazine complexes that are not metabolized by the body. A case of levetiracetam hyperpigmentation has also been described (1).


Skin hyperpigmentation, Anticonvulsant drugs