Erythema multiforme associated with varicella.


How to Cite

Delvecchio A. 2016. Erythema multiforme associated with varicella. Eur. J. Pediat. Dermatol. 26 (2): 123. 10.26326/2281-9649.26.2.1238.


Delvecchio A.
pp. 123


Erythema multiforme (EM) is a hypersensitivity dermatitis to different antigens including viral, bacterial and mycotic agents (1, 2, 3).
EM is part of a spectrum of disorders ranging in severity from papular EM to toxic epidermal necrolysis. Our case was characterized by large superficial blisters with centrifugal evolution centered by a varicella lesion. In the literature less than 10 cases of erythema multiforme associated with chickenpox have been described (3); in these cases erythema multiforme usually appears 2-10 days after the first clinical manifestations of varicella.
From a pathogenetic point of view it would be a delayed-type hypersensitivity reaction to viral antigens, which would involve the recruitment of virus-specific CD4+ cells with consequent release of interferon γ and epidermal damage (3).