Metastatic Merkel cell carcinoma.

How to Cite

Levato E., Troia M. 2014. Metastatic Merkel cell carcinoma. Eur. J. Pediat. Dermatol. 24 (3): 192.


Levato E. Troia M.
pp. 192


Case report. A 91-year-old woman was first observed due to a neoformation of the leg dating from 10 years according to the history. The physical examination showed a nodule of about 1 cm in diameter, with eroded surface, non-tender, mobile on the deep layers (Fig. 2), leading to diagnose squamous cell cr. The patient asked to postpone the removal of a couple of months. 2 months later the lesion had changed significantly. The physical examination showed a 3 cm ulcerated plaque and in the proximal skin below the knee about twenty asymptomatic nodules of 3-9 mm (Fig. 1) covered by intact skin, hard-elastic and movable on the superficial and deep layers. A biopsy of the primary lesion and removal of a metastatic nodule was performed. The histology showed in the ulcerated plaque and in the secondary nodule a proliferation of small basophilic cells (Fig. 3) with many mitoses and invasion of vessels. Immunohistochemistry confirmed the suspicion of metastatic Merkel cell cr. The patient began radiation therapy.


Merkel cell carcinoma