TY - JOUR AU - Sadikov, N.I. AU - Aliyev, A.L. AU - Kuziyev, D.V. AU - Akhrorkhonov, R.A. PY - 2023/05/01 Y2 - 2024/03/29 TI - Immunological status in acute pneumonia in children under 2 years old with atopic dermatitis: A parallel group clinical trial. JF - European Journal of Pediatric Dermatology JA - Eur. J. Pediat. Dermatol. VL - 33 IS - 2 SE - DO - 10.26326/2281-9649.33.2.2477 UR - https://ejpd.com/index.php/journal/article/view/2477 SP - 77-80 AB - <p><em>Background</em>. Atopic dermatitis (AD) is a chronic skin disorder that affects children worldwide. AD children have an increased risk of developing asthma and other allergic diseases. Acute pneumonia is a respiratory infection that can cause significant morbidity and mortality, especially in children under 2 years old. However, it is not clear how the immune system responds to acute pneumonia in AD children under 2 years old.<br /><em>Objective</em>. This study aimed to investigate the immune response of children under 2 years old with AD who develop acute pneumonia and compare it with children without AD who develop acute pneumonia.<br /><em>Materials and Methods</em>. The study included children under 2 years old hospitalized with a diagnosis of acute pneumonia. Participants were divided into two groups: Group A included children with AD who developed acute pneumonia, and Group B included children without AD who developed the same infection.<br /><em>Results</em>. The study included 50 children, 25 in each group. Group A had significantly higher levels of IL-4, IL-5, and IL-6 on admission to the hospital compared to Group B. Children with AD had a longer hospital stay and required oxygen therapy more frequently.<br /><em>Conclusion</em>. Children under 2 years old with AD who develop acute pneumonia have a different immune response compared to those without AD. They also have a longer hospital stay and are more likely to require oxygen therapy.</p> ER -